This Division Series saw the Athletics defeat the Twins, 3–0. The Athletics and Tigers met in the AL Championship Series (ALCS), where a Detroit sweep made the Tigers the American League champions. The Tigers then faced the St. Louis Cardinals in the 2006 World Series, and lost, four games to one, despite having home-field advantage.

Playoff race

The AL playoff race of 2006 was unusually dramatic, with the last divisional championship and the wild card berth undecided until the final day of the season, and the most unlikely of all of the AL's playoff contenders taking the top spot in the AL Central and the second seed.

In the AL East, the New York Yankees (97–65) clinched the division when the Boston Red Sox were eliminated from the playoffs by the Minnesota Twins (96–66) on September 20^th. The Oakland Athletics (92–69) clinched the AL West on September 26^th, and in the AL Central, the Twins won the division by a single game over the Wild Card Detroit Tigers (95–67) after Detroit—who had led the division for the entire season—lost their last five games. Minnesota had set a torrid pace since June 7^th, after a horrible start. The Twins sewed up their playoff berth with an 8–1 win over the Kansas City Royals, on Monday, September 25^th. They clinched the Central Division title, their fourth in five years, with a 5–1 victory over the Chicago White Sox, and a 10–8 Detroit loss to the Royals on the last day of the season. The Twins' 96–66 mark is their best since the 98–64 AL West Champion Twins of 1970.